mapbayr Package for Bayesian MAP Estimate of Pharmacokinetic Parameter in Model Informed Precision Dosing

mapbayr Package for Bayesian MAP Estimate of Pharmacokinetic Parameter in Model Informed Precision Dosing

Choose a Model/ Dose

IB911
CA901

Observation
Time (Hour)	Ibru (ng/mL)	DHibru (ng/mL)

Administration
Dose
# of Simulation

Observations	Time	Concentration
First
Second
Third

Administration
Dose
Duration

Patient/Protocol
$$\text{BSA} (m^{2})$$
Target AUC
# of Simulations

Masud Rana, PhD (Biostatistics)

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Acknowledgement

The app is designed based on the materials presented in the article Easy and reliable maximum a posteriori Bayesian estimation of pharmacokinetic parameters with the open-source R package mapbayr . The details can be found there.

Warning!

These applications are provided for illustrative purpose only! Although they may be based on models built from clinical data, they should not be used to directly to individualize doses of patients. These applications are distributed without any warantee.

Figure
Table

Predicted Concentation with 90% Simulation-based Confidence Interval

Distribution of Pharmacokinetic Parameters

Data

Results